Written by Jill & Alex, FDMB.
The Tight Regulation Protocol with Lantus or Levemir describes what we've fondly dubbed "New Dose Wonkiness" (NDW) here in the Lantus, Levemir, & Biosimilars ISG:
"Many cats will occasionally react to an increased dose with increased BGs - within the first 2 to 3 days after an increase, usually lasting for less than 24 hours. Nobody really knows what the reason for this phenomenon is (perhaps a "panicky liver"?) - hold the dose and ignore the fluctuations."
You might also see this happening while following the Start Low, Go Slow Method.
NOTE:
Written by Julie & Punkin, FDMB.
when you increase a dose of lantus, you would expect the BG numbers to go lower, right? that's logical. more insulin = lower numbers. only there is a lag time sometimes - increase the dose and for some reason the numbers go higher. that can last a day or so, and then suddenly you start seeing those lower numbers you expected. we call those higher numbers "New Dose Wonkiness" or NDW.
this is the reason we wait following each dose increase to let it settle and see what it's really doing.
now not every cat does that, of course. ECID. sometimes you increase the dose and you immediately see lower numbers. the point of this post is to say that IF you increase a dose AND you see higher numbers, give it a couple of days for things to settle down and then you can assess the dose to see what it's really doing.
the second part of the post is saying that this doesn't apply to a cat when you DECREASE a dose. let's say mookie drops below 50 today and you decrease the dose. if you see higher numbers following the dose decrease, that's not NDW. NDW only applies when you're increasing a dose. higher numbers following a dose decrease can be from one of two things. one possibility is that it simply isn't enough insulin. another possibility is if the cat dropped quickly, or if the cat dropped into a lower range of numbers than it was used to, that can cause a bounce.
BOUNCING
Here is an example of a bounce from someone's recent condo:
you can spot a bounce this way (this only took me 6 months to learn and a bunch of people explaining it! i'm a slow learner!)
yesterday morning you had a 215 - then it went 235, 271, 270, and then 308 this morning - basically straight up. no curve. and then look backwards in the ss and the night before was that sweet little 148 12 hours earlier.
if you imagine that night-time cycle, starting at 148, kitty probably went down in a nice little curve, hitting something under 100 mid-cycle. that lower-than-usual number would've shocked her body. they get accustomed to whatever range they're in, and any sudden dip lower can set this off.
"HELLO WE"VE GOT A 911 HERE- KITTY'S GOING DOWN!" yells Mr. Liver. Fortunately, mr liver has a storehouse of counter-regulatory hormones and stored sugar (in case kitty needs a little nommy sweets in the middle of the night) and when Kitty gets into a range of numbers lower than usual, Mr. Liver lets loose with the sugar and the hormones and sends Kitty on a rocket to the moon. this is the cat's body's protective mechanism to keep the cat from becoming hypoglycemic. unfortunately, mr liver doesn't seem to know that anything above 40ish isn't a crisis and it will do this regardless of the range of numbers, even at 200 if the cat has become accustomed to 400.
A second cause of a bounce is if a cat drops very quickly. 100 points in an hour, for example, regardless of the range the BG number is in, can cause a bounce as well.
So, what to do now? don't increase the dose because of these higher numbers. once this bounce clears, which can take up to 3 days of high numbers if mr liver is super-active, then if you had increased the dose, it would be too high. you are entering the phase of treatment that we say requires "Patience Pants." when you think you're seeing a bounce, you have to wait it out, then you can see what the dose really does. You will know the bounce has cleared when you start seeing numbers you were seeing before - like that 148 again.
Sources:
Jill & Alex (GA). “New Dose Wonkiness (NDW) and Failed Reductions.” Feline Diabetes Message Board, 21 June 2011, https://www.felinediabetes.com/FDMB/threads/new-dose-wonkiness-ndw-and-failed-reductions.46012/
The Tight Regulation Protocol with Lantus or Levemir describes what we've fondly dubbed "New Dose Wonkiness" (NDW) here in the Lantus, Levemir, & Biosimilars ISG:
"Many cats will occasionally react to an increased dose with increased BGs - within the first 2 to 3 days after an increase, usually lasting for less than 24 hours. Nobody really knows what the reason for this phenomenon is (perhaps a "panicky liver"?) - hold the dose and ignore the fluctuations."
You might also see this happening while following the Start Low, Go Slow Method.
NOTE:
- NDW usually lasts for less than 24 hours and is usually seen in the second day following a dose increase.
- The concept of "New Dose Wonkiness" is NOT applied to higher numbers which may be seen after a dose reduction.
- There is no "NDW" following a dose reduction nor do we hold a reduced dose 6 cycles (as done with dose increases) to "fill the insulin depot".
- "Settling time" does not apply to dose reductions. We don't wait for a reduction to "settle".
- For those following the Tight Regulation Protocol: "If the cat will not stay in the normal range after a reduction, immediately increase the dose again to the last good dose."
Written by Julie & Punkin, FDMB.
when you increase a dose of lantus, you would expect the BG numbers to go lower, right? that's logical. more insulin = lower numbers. only there is a lag time sometimes - increase the dose and for some reason the numbers go higher. that can last a day or so, and then suddenly you start seeing those lower numbers you expected. we call those higher numbers "New Dose Wonkiness" or NDW.
this is the reason we wait following each dose increase to let it settle and see what it's really doing.
now not every cat does that, of course. ECID. sometimes you increase the dose and you immediately see lower numbers. the point of this post is to say that IF you increase a dose AND you see higher numbers, give it a couple of days for things to settle down and then you can assess the dose to see what it's really doing.
the second part of the post is saying that this doesn't apply to a cat when you DECREASE a dose. let's say mookie drops below 50 today and you decrease the dose. if you see higher numbers following the dose decrease, that's not NDW. NDW only applies when you're increasing a dose. higher numbers following a dose decrease can be from one of two things. one possibility is that it simply isn't enough insulin. another possibility is if the cat dropped quickly, or if the cat dropped into a lower range of numbers than it was used to, that can cause a bounce.
BOUNCING
Here is an example of a bounce from someone's recent condo:
you can spot a bounce this way (this only took me 6 months to learn and a bunch of people explaining it! i'm a slow learner!)
yesterday morning you had a 215 - then it went 235, 271, 270, and then 308 this morning - basically straight up. no curve. and then look backwards in the ss and the night before was that sweet little 148 12 hours earlier.
if you imagine that night-time cycle, starting at 148, kitty probably went down in a nice little curve, hitting something under 100 mid-cycle. that lower-than-usual number would've shocked her body. they get accustomed to whatever range they're in, and any sudden dip lower can set this off.
"HELLO WE"VE GOT A 911 HERE- KITTY'S GOING DOWN!" yells Mr. Liver. Fortunately, mr liver has a storehouse of counter-regulatory hormones and stored sugar (in case kitty needs a little nommy sweets in the middle of the night) and when Kitty gets into a range of numbers lower than usual, Mr. Liver lets loose with the sugar and the hormones and sends Kitty on a rocket to the moon. this is the cat's body's protective mechanism to keep the cat from becoming hypoglycemic. unfortunately, mr liver doesn't seem to know that anything above 40ish isn't a crisis and it will do this regardless of the range of numbers, even at 200 if the cat has become accustomed to 400.
A second cause of a bounce is if a cat drops very quickly. 100 points in an hour, for example, regardless of the range the BG number is in, can cause a bounce as well.
So, what to do now? don't increase the dose because of these higher numbers. once this bounce clears, which can take up to 3 days of high numbers if mr liver is super-active, then if you had increased the dose, it would be too high. you are entering the phase of treatment that we say requires "Patience Pants." when you think you're seeing a bounce, you have to wait it out, then you can see what the dose really does. You will know the bounce has cleared when you start seeing numbers you were seeing before - like that 148 again.
Sources:
Jill & Alex (GA). “New Dose Wonkiness (NDW) and Failed Reductions.” Feline Diabetes Message Board, 21 June 2011, https://www.felinediabetes.com/FDMB/threads/new-dose-wonkiness-ndw-and-failed-reductions.46012/
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